2021 American Athletic Conference Leaders Sacks - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Houston | 2 | 4.0 | 30 | 2.00 |
| 1 | Tulsa | 2 | 4.0 | 28 | 2.00 |
| 3 | Tulane | 2 | 3.0 | 32 | 1.50 |
| 3 | East Carolina | 1 | 3.0 | 23 | 3.00 |
| 3 | Cincinnati | 2 | 3.0 | 14 | 1.50 |
| 3 | UCF | 2 | 3.0 | 12 | 1.50 |
| 7 | South Florida | 2 | 2.0 | 15 | 1.00 |
| 7 | Memphis | 1 | 2.0 | 14 | 2.00 |
| 7 | SMU | 1 | 2.0 | 14 | 2.00 |
| 10 | Temple | 2 | 1.0 | 8 | 0.50 |