2021 American Athletic Conference Leaders Sacks - Games vs. FBS Teams With Winning Record Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Cincinnati | 8 | 23.0 | 136 | 2.88 |
| 2 | Tulane | 9 | 21.0 | 135 | 2.33 |
| 3 | Memphis | 7 | 18.0 | 123 | 2.57 |
| 4 | East Carolina | 6 | 15.0 | 121 | 2.50 |
| 4 | Houston | 5 | 15.0 | 94 | 3.00 |
| 6 | Navy | 10 | 12.0 | 73 | 1.20 |
| 7 | SMU | 4 | 9.0 | 58 | 2.25 |
| 8 | Tulsa | 5 | 8.0 | 49 | 1.60 |
| 9 | UCF | 4 | 6.0 | 33 | 1.50 |
| 10 | Temple | 5 | 5.0 | 40 | 1.00 |
| 10 | South Florida | 8 | 5.0 | 29 | 0.63 |