2021 American Athletic Conference Leaders Sacks - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Houston | 13 | 42.0 | 267 | 3.23 |
| 2 | UCF | 12 | 35.0 | 221 | 2.92 |
| 3 | Cincinnati | 11 | 27.0 | 154 | 2.46 |
| 4 | Tulane | 8 | 26.0 | 145 | 3.25 |
| 5 | Memphis | 11 | 25.0 | 174 | 2.27 |
| 6 | SMU | 10 | 24.0 | 148 | 2.40 |
| 7 | Tulsa | 9 | 20.0 | 99 | 2.22 |
| 8 | East Carolina | 10 | 18.0 | 113 | 1.80 |
| 9 | Navy | 9 | 11.0 | 79 | 1.22 |
| 9 | Temple | 10 | 11.0 | 79 | 1.10 |
| 11 | South Florida | 8 | 5.0 | 27 | 0.63 |