2021 American Athletic Conference Leaders Sacks - All Games through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Houston | 14 | 43.0 | 277 | 3.07 |
| 2 | Cincinnati | 14 | 39.0 | 231 | 2.79 |
| 3 | UCF | 13 | 36.0 | 233 | 2.77 |
| 4 | Tulane | 12 | 34.0 | 217 | 2.83 |
| 5 | Memphis | 12 | 27.0 | 188 | 2.25 |
| 6 | East Carolina | 12 | 26.0 | 182 | 2.17 |
| 6 | SMU | 12 | 26.0 | 159 | 2.17 |
| 6 | Tulsa | 13 | 26.0 | 134 | 2.00 |
| 9 | Navy | 12 | 16.0 | 111 | 1.33 |
| 10 | Temple | 12 | 15.0 | 108 | 1.25 |
| 11 | USF | 12 | 9.0 | 53 | 0.75 |