2021 American Athletic Conference Leaders Sacks - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | University of Central Florida | 8 | 30.0 | 200 | 3.75 |
| 2 | University of Houston | 8 | 25.0 | 162 | 3.13 |
| 3 | The University of Tulsa | 7 | 17.0 | 82 | 2.43 |
| 4 | University of Cincinnati | 5 | 15.0 | 92 | 3.00 |
| 4 | Southern Methodist University | 7 | 15.0 | 88 | 2.14 |
| 6 | University of Memphis | 4 | 9.0 | 65 | 2.25 |
| 7 | Temple University | 6 | 8.0 | 54 | 1.33 |
| 7 | Tulane University | 2 | 8.0 | 47 | 4.00 |
| 9 | East Carolina University | 5 | 6.0 | 32 | 1.20 |
| 10 | U.S. Naval Academy | 2 | 4.0 | 38 | 2.00 |
| 11 | University of South Florida | 3 | 3.0 | 22 | 1.00 |