2021 American Athletic Conference Leaders Sacks - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | University of Cincinnati | 3 | 12.0 | 77 | 4.00 |
| 2 | Tulane University | 4 | 8.0 | 72 | 2.00 |
| 2 | East Carolina University | 2 | 8.0 | 69 | 4.00 |
| 4 | The University of Tulsa | 4 | 6.0 | 35 | 1.50 |
| 5 | U.S. Naval Academy | 3 | 5.0 | 32 | 1.67 |
| 6 | Temple University | 2 | 4.0 | 29 | 2.00 |
| 6 | University of South Florida | 4 | 4.0 | 26 | 1.00 |
| 8 | University of Memphis | 1 | 2.0 | 14 | 2.00 |
| 8 | Southern Methodist University | 2 | 2.0 | 11 | 1.00 |
| 10 | University of Central Florida | 1 | 1.0 | 12 | 1.00 |
| 10 | University of Houston | 1 | 1.0 | 10 | 1.00 |