2021 American Athletic Conference Leaders Sacks - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Houston | 11 | 36.0 | 226 | 3.27 |
| 2 | Cincinnati | 11 | 35.0 | 214 | 3.18 |
| 3 | UCF | 10 | 33.0 | 221 | 3.30 |
| 4 | Tulane | 9 | 26.0 | 150 | 2.89 |
| 5 | Memphis | 10 | 25.0 | 174 | 2.50 |
| 6 | SMU | 10 | 22.0 | 132 | 2.20 |
| 7 | Tulsa | 10 | 21.0 | 103 | 2.10 |
| 8 | East Carolina | 10 | 18.0 | 130 | 1.80 |
| 9 | Navy | 12 | 16.0 | 111 | 1.33 |
| 10 | Temple | 9 | 12.0 | 86 | 1.33 |
| 11 | South Florida | 9 | 6.0 | 36 | 0.67 |