2021 American Athletic Conference Leaders Sacks - Games in August/September Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | University of Houston | 4 | 12.0 | 88 | 3.00 |
| 2 | Tulane University | 4 | 11.0 | 90 | 2.75 |
| 2 | The University of Tulsa | 4 | 11.0 | 59 | 2.75 |
| 4 | East Carolina University | 4 | 10.0 | 67 | 2.50 |
| 5 | Southern Methodist University | 4 | 7.0 | 39 | 1.75 |
| 6 | University of Memphis | 4 | 6.0 | 51 | 1.50 |
| 6 | Temple University | 4 | 6.0 | 46 | 1.50 |
| 8 | University of Cincinnati | 3 | 4.0 | 20 | 1.33 |
| 8 | U.S. Naval Academy | 3 | 4.0 | 20 | 1.33 |
| 10 | University of South Florida | 4 | 3.0 | 17 | 0.75 |
| 11 | University of Central Florida | 3 | 1.0 | 9 | 0.33 |