2025 American Conference Leaders Sacks - Games vs. FBS Power 5 Conference Teams Only through 12/13/2025
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Tulsa | 2 | 5.0 | 42 | 2.50 |
| 2 | Temple | 2 | 4.0 | 32 | 2.00 |
| 2 | Tulane | 3 | 4.0 | 31 | 1.33 |
| 4 | North Texas | 1 | 3.0 | 16 | 3.00 |
| 4 | Rice | 1 | 3.0 | 6 | 3.00 |
| 6 | Charlotte | 2 | 2.0 | 9 | 1.00 |
| 6 | East Carolina | 2 | 2.0 | 6 | 1.00 |
| 6 | USF | 2 | 2.0 | 5 | 1.00 |
| 9 | Memphis | 1 | 1.0 | 9 | 1.00 |
| 9 | UAB | 1 | 1.0 | 5 | 1.00 |