2024 American Athletic Conference Leaders Sacks - Games vs. FBS Power 5 Conference Teams Only through 01/04/2025
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Memphis | 2 | 4.0 | 33 | 2.00 |
| 1 | Charlotte | 2 | 4.0 | 31 | 2.00 |
| 1 | Tulane | 3 | 4.0 | 27 | 1.33 |
| 1 | Navy | 1 | 4.0 | 14 | 4.00 |
| 5 | South Florida | 2 | 3.0 | 36 | 1.50 |
| 5 | Rice | 1 | 3.0 | 16 | 3.00 |
| 5 | UAB | 1 | 3.0 | 13 | 3.00 |
| 5 | Temple | 1 | 3.0 | 13 | 3.00 |
| 9 | East Carolina | 1 | 2.0 | 8 | 2.00 |
| 10 | North Texas | 1 | 1.0 | 11 | 1.00 |
| 10 | UTSA | 1 | 1.0 | 10 | 1.00 |
| 10 | Florida Atlantic | 1 | 1.0 | 4 | 1.00 |