2025 Conference USA Leaders Passes Defended - Games vs. FBS non-Power 5 Conference Teams Only through 10/08/2025
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Louisiana Tech | 3 | 8 | 24 | 32 | 10.67 |
| 2 | Western Kentucky | 5 | 5 | 18 | 23 | 4.60 |
| 3 | Middle Tennessee State | 4 | 2 | 15 | 17 | 4.25 |
| 3 | Sam Houston State | 4 | 2 | 15 | 17 | 4.25 |
| 3 | Missouri State | 3 | 1 | 15 | 16 | 5.33 |
| 3 | UTEP | 4 | 1 | 15 | 16 | 4.00 |
| 7 | Liberty | 5 | 4 | 14 | 18 | 3.60 |
| 8 | FIU | 3 | 4 | 12 | 16 | 5.33 |
| 8 | New Mexico State | 4 | 4 | 12 | 16 | 4.00 |
| 8 | Kennesaw State | 2 | 1 | 12 | 13 | 6.50 |
| 11 | Jacksonville State | 3 | 1 | 11 | 12 | 4.00 |
| 12 | Delaware | 3 | 2 | 9 | 11 | 3.67 |