2025 Conference USA Leaders Passes Defended - Games vs. FBS non-Power 5 Conference Teams Only through 12/13/2025
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Louisiana Tech | 9 | 17 | 51 | 68 | 7.56 |
| 2 | Kennesaw State | 10 | 8 | 44 | 52 | 5.20 |
| 3 | FIU | 10 | 12 | 43 | 55 | 5.50 |
| 3 | New Mexico State | 10 | 12 | 43 | 55 | 5.50 |
| 5 | Western Kentucky | 10 | 7 | 41 | 48 | 4.80 |
| 5 | Missouri State | 9 | 6 | 41 | 47 | 5.22 |
| 7 | Jacksonville State | 11 | 10 | 38 | 48 | 4.36 |
| 8 | Middle Tennessee State | 10 | 9 | 37 | 46 | 4.60 |
| 9 | Liberty | 11 | 6 | 36 | 42 | 3.82 |
| 10 | UTEP | 10 | 4 | 32 | 36 | 3.60 |
| 11 | Sam Houston State | 10 | 6 | 26 | 32 | 3.20 |
| 12 | Delaware | 9 | 9 | 25 | 34 | 3.78 |