2025 Conference USA Leaders Passes Defended - Games vs. FBS Teams With Winning Record Only through 11/22/2025
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Kennesaw State | 6 | 4 | 23 | 27 | 4.50 |
| 2 | New Mexico State | 6 | 8 | 22 | 30 | 5.00 |
| 3 | UTEP | 6 | 4 | 20 | 24 | 4.00 |
| 3 | Louisiana Tech | 4 | 3 | 20 | 23 | 5.75 |
| 3 | Middle Tennessee State | 5 | 3 | 20 | 23 | 4.60 |
| 6 | FIU | 5 | 3 | 19 | 22 | 4.40 |
| 7 | Missouri State | 5 | 1 | 18 | 19 | 3.80 |
| 8 | Western Kentucky | 5 | 3 | 16 | 19 | 3.80 |
| 8 | Liberty | 6 | 3 | 16 | 19 | 3.17 |
| 10 | Jacksonville State | 3 | 6 | 15 | 21 | 7.00 |
| 10 | Sam Houston State | 6 | 3 | 15 | 18 | 3.00 |
| 12 | Delaware | 6 | 5 | 13 | 18 | 3.00 |