2025 Conference USA Leaders Passes Defended - Games vs. FBS Power 5 Conference Teams Only through 11/22/2025
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Louisiana Tech | 2 | 1 | 6 | 7 | 3.50 |
| 1 | FIU | 1 | 0 | 6 | 6 | 6.00 |
| 3 | Delaware | 2 | 2 | 5 | 7 | 3.50 |
| 3 | Sam Houston State | 2 | 2 | 5 | 7 | 3.50 |
| 3 | Western Kentucky | 1 | 1 | 5 | 6 | 6.00 |
| 3 | Missouri State | 2 | 1 | 5 | 6 | 3.00 |
| 3 | Kennesaw State | 2 | 0 | 5 | 5 | 2.50 |
| 8 | UTEP | 1 | 1 | 3 | 4 | 4.00 |
| 9 | Jacksonville State | 1 | 0 | 2 | 2 | 2.00 |
| 10 | New Mexico State | 1 | 2 | 1 | 3 | 3.00 |
| 11 | Middle Tennessee State | 1 | 1 | 0 | 1 | 1.00 |