2025 Conference USA Leaders Passes Defended - Games vs. FBS non-Power 5 Conference Teams Only through 11/01/2025
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Louisiana Tech | 6 | 10 | 40 | 50 | 8.33 |
| 2 | Missouri State | 5 | 5 | 26 | 31 | 6.20 |
| 2 | Kennesaw State | 5 | 3 | 28 | 31 | 6.20 |
| 4 | New Mexico State | 7 | 9 | 27 | 36 | 5.14 |
| 5 | Western Kentucky | 8 | 7 | 33 | 40 | 5.00 |
| 6 | FIU | 6 | 7 | 22 | 29 | 4.83 |
| 7 | UTEP | 6 | 2 | 23 | 25 | 4.17 |
| 8 | Liberty | 7 | 5 | 24 | 29 | 4.14 |
| 9 | Middle Tennessee State | 6 | 3 | 20 | 23 | 3.83 |
| 9 | Jacksonville State | 6 | 2 | 21 | 23 | 3.83 |
| 11 | Delaware | 6 | 3 | 17 | 20 | 3.33 |
| 12 | Sam Houston State | 7 | 4 | 17 | 21 | 3.00 |