2025 Conference USA Leaders Passes Defended - Games in August/September Only through 11/01/2025
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Louisiana Tech | 5 | 11 | 35 | 46 | 9.20 |
| 2 | Western Kentucky | 5 | 4 | 20 | 24 | 4.80 |
| 2 | Kennesaw State | 5 | 1 | 20 | 21 | 4.20 |
| 4 | FIU | 4 | 4 | 17 | 21 | 5.25 |
| 4 | Jacksonville State | 5 | 3 | 17 | 20 | 4.00 |
| 4 | UTEP | 5 | 2 | 17 | 19 | 3.80 |
| 7 | Missouri State | 5 | 3 | 16 | 19 | 3.80 |
| 8 | Sam Houston State | 4 | 2 | 14 | 16 | 4.00 |
| 9 | New Mexico State | 4 | 4 | 13 | 17 | 4.25 |
| 9 | Liberty | 5 | 3 | 13 | 16 | 3.20 |
| 11 | Delaware | 4 | 4 | 12 | 16 | 4.00 |
| 12 | Middle Tennessee State | 5 | 3 | 11 | 14 | 2.80 |