2022 American Athletic Conference Leaders Sacks - Games vs. Ranked Teams Only (AP Poll) through 01/09/2023
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | SMU | 2 | 6.0 | 45 | 3.00 |
| 2 | Navy | 1 | 5.0 | 30 | 5.00 |
| 2 | East Carolina | 1 | 5.0 | 28 | 5.00 |
| 4 | South Florida | 1 | 4.0 | 13 | 4.00 |
| 5 | UCF | 2 | 3.0 | 21 | 1.50 |
| 6 | Houston | 1 | 2.0 | 18 | 2.00 |
| 6 | Memphis | 2 | 2.0 | 13 | 1.00 |
| 6 | Tulsa | 1 | 2.0 | 3 | 2.00 |
| 9 | Cincinnati | 1 | 1.0 | 5 | 1.00 |