2022 American Athletic Conference Leaders Sacks - Games vs. FBS Teams With Winning Record Only through 01/09/2023
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | East Carolina | 8 | 20.0 | 138 | 2.50 |
| 1 | Navy | 8 | 20.0 | 111 | 2.50 |
| 3 | Houston | 6 | 18.0 | 108 | 3.00 |
| 4 | SMU | 8 | 15.0 | 105 | 1.88 |
| 4 | Temple | 6 | 15.0 | 101 | 2.50 |
| 4 | Tulane | 10 | 15.0 | 93 | 1.50 |
| 7 | UCF | 8 | 12.0 | 81 | 1.50 |
| 8 | Tulsa | 7 | 11.0 | 78 | 1.57 |
| 8 | Cincinnati | 6 | 11.0 | 76 | 1.83 |
| 10 | South Florida | 8 | 10.0 | 46 | 1.25 |
| 11 | Memphis | 6 | 7.0 | 51 | 1.17 |