2025 Atlantic Coast Conference Leaders Passes Defended - Games in August/September Only through 11/22/2025
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | SMU | 4 | 6 | 25 | 31 | 7.75 |
| 2 | California | 5 | 5 | 22 | 27 | 5.40 |
| 3 | Syracuse | 5 | 3 | 23 | 26 | 5.20 |
| 4 | Louisville | 4 | 6 | 16 | 22 | 5.50 |
| 4 | Clemson | 4 | 3 | 19 | 22 | 5.50 |
| 4 | Virginia | 5 | 3 | 19 | 22 | 4.40 |
| 7 | Wake Forest | 4 | 1 | 18 | 19 | 4.75 |
| 8 | Duke | 5 | 4 | 14 | 18 | 3.60 |
| 8 | NC State | 5 | 3 | 15 | 18 | 3.60 |
| 10 | Boston College | 4 | 2 | 15 | 17 | 4.25 |
| 11 | Florida State | 4 | 6 | 10 | 16 | 4.00 |
| 11 | Georgia Tech | 5 | 1 | 15 | 16 | 3.20 |
| 13 | North Carolina | 4 | 4 | 11 | 15 | 3.75 |
| 13 | Virginia Tech | 5 | 2 | 13 | 15 | 3.00 |
| 13 | Stanford | 5 | 1 | 14 | 15 | 3.00 |
| 16 | Pittsburgh | 4 | 3 | 11 | 14 | 3.50 |
| 17 | Miami (FL) | 4 | 3 | 10 | 13 | 3.25 |