2025 Conference USA Leaders Passes Defended - Games vs. FBS Power 5 Conference Teams Only through 10/08/2025
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Louisiana Tech | 1 | 1 | 5 | 6 | 6.00 |
| 1 | Missouri State | 2 | 1 | 5 | 6 | 3.00 |
| 1 | UTEP | 1 | 1 | 3 | 4 | 4.00 |
| 1 | Middle Tennessee State | 1 | 1 | 0 | 1 | 1.00 |
| 5 | FIU | 1 | 0 | 6 | 6 | 6.00 |
| 5 | Kennesaw State | 2 | 0 | 5 | 5 | 2.50 |
| 5 | Delaware | 1 | 0 | 3 | 3 | 3.00 |
| 5 | Jacksonville State | 1 | 0 | 2 | 2 | 2.00 |
| 5 | Sam Houston State | 1 | 0 | 1 | 1 | 1.00 |