2025 Conference USA Leaders Total Defense - Games vs. Ranked Teams Only (AP Poll) through 11/13/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Missouri State | 1 | 233 | 364 | 57 | 597 | 10.47 | 597.0 |
| 2 | Liberty | 1 | 227 | 213 | 67 | 440 | 6.57 | 440.0 |
| 2 | Kennesaw State | 1 | 313 | 280 | 67 | 593 | 8.85 | 593.0 |
| 4 | Sam Houston State | 1 | 264 | 343 | 69 | 607 | 8.80 | 607.0 |
| 5 | UTEP | 1 | 226 | 114 | 81 | 340 | 4.20 | 340.0 |