2025 Conference USA Leaders Total Defense - Games at Home Only through 09/13/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Sam Houston State | 1 | 155 | 249 | 56 | 404 | 7.21 | 404.0 |
| 2 | Kennesaw State | 1 | 79 | 215 | 63 | 294 | 4.67 | 294.0 |
| 2 | Liberty | 1 | 184 | 132 | 63 | 316 | 5.02 | 316.0 |
| 4 | Jacksonville State | 1 | 199 | 335 | 66 | 534 | 8.09 | 534.0 |
| 5 | Missouri State | 1 | 167 | 281 | 70 | 448 | 6.40 | 448.0 |
| 6 | Middle Tennessee State | 1 | 150 | 193 | 74 | 343 | 4.64 | 343.0 |
| 7 | UTEP | 1 | 76 | 295 | 76 | 371 | 4.88 | 371.0 |
| 8 | Louisiana Tech | 2 | 153 | 426 | 125 | 579 | 4.63 | 289.5 |
| 9 | Western Kentucky | 2 | 326 | 314 | 133 | 640 | 4.81 | 320.0 |
| 10 | Delaware | 2 | 375 | 495 | 138 | 870 | 6.30 | 435.0 |
| 11 | New Mexico State | 2 | 209 | 421 | 145 | 630 | 4.34 | 315.0 |
| 12 | FIU | 2 | 240 | 584 | 151 | 824 | 5.46 | 412.0 |