2025 Conference USA Leaders Total Defense - Games vs. FBS (I-A) Teams Only through 09/13/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Middle Tennessee State | 2 | 356 | 449 | 118 | 805 | 6.82 | 402.5 |
| 2 | Western Kentucky | 2 | 480 | 410 | 124 | 890 | 7.18 | 445.0 |
| 3 | Louisiana Tech | 2 | 155 | 518 | 125 | 673 | 5.38 | 336.5 |
| 4 | Liberty | 2 | 496 | 198 | 130 | 694 | 5.34 | 347.0 |
| 5 | Delaware | 2 | 305 | 614 | 141 | 919 | 6.52 | 459.5 |
| 6 | UTEP | 2 | 353 | 347 | 142 | 700 | 4.93 | 350.0 |
| 6 | Kennesaw State | 2 | 443 | 498 | 142 | 941 | 6.63 | 470.5 |
| 8 | FIU | 2 | 344 | 543 | 146 | 887 | 6.08 | 443.5 |
| 9 | New Mexico State | 2 | 494 | 455 | 162 | 949 | 5.86 | 474.5 |
| 10 | Missouri State | 3 | 591 | 728 | 184 | 1319 | 7.17 | 439.7 |
| 11 | Jacksonville State | 3 | 526 | 840 | 202 | 1366 | 6.76 | 455.3 |
| 12 | Sam Houston State | 3 | 383 | 944 | 219 | 1327 | 6.06 | 442.3 |