2025 Conference USA Leaders Total Defense - Games vs. Ranked Teams Only (AP Poll) through 09/13/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | UTEP | 1 | 226 | 114 | 81 | 340 | 4.20 | 340.0 |
| 2 | Louisiana Tech | 1 | 128 | 237 | 75 | 365 | 4.87 | 365.0 |
| 3 | FIU | 1 | 209 | 200 | 64 | 409 | 6.39 | 409.0 |
| 4 | Kennesaw State | 1 | 313 | 280 | 67 | 593 | 8.85 | 593.0 |
| 5 | Missouri State | 1 | 233 | 364 | 57 | 597 | 10.47 | 597.0 |