2025 Atlantic Coast Conference Leaders Passes Defended - Games in November Only through 12/20/2025
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Clemson | 5 | 4 | 29 | 33 | 6.60 |
| 2 | Virginia | 4 | 4 | 23 | 27 | 6.75 |
| 2 | California | 4 | 2 | 23 | 25 | 6.25 |
| 4 | Miami (FL) | 5 | 5 | 22 | 27 | 5.40 |
| 5 | Wake Forest | 5 | 0 | 21 | 21 | 4.20 |
| 6 | Stanford | 4 | 2 | 19 | 21 | 5.25 |
| 7 | NC State | 4 | 3 | 16 | 19 | 4.75 |
| 8 | Pittsburgh | 4 | 8 | 15 | 23 | 5.75 |
| 9 | Duke | 5 | 3 | 14 | 17 | 3.40 |
| 9 | Louisville | 5 | 2 | 14 | 16 | 3.20 |
| 11 | North Carolina | 4 | 1 | 13 | 14 | 3.50 |
| 12 | SMU | 4 | 5 | 11 | 16 | 4.00 |
| 13 | Georgia Tech | 4 | 1 | 10 | 11 | 2.75 |
| 13 | Virginia Tech | 4 | 1 | 10 | 11 | 2.75 |
| 13 | Syracuse | 3 | 0 | 10 | 10 | 3.33 |
| 16 | Florida State | 5 | 3 | 9 | 12 | 2.40 |
| 16 | Boston College | 4 | 1 | 9 | 10 | 2.50 |