2021 Atlantic Coast Conference Leaders Passes Defended - Games in November Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Clemson | 4 | 5 | 20 | 25 | 6.25 |
| 2 | North Carolina | 4 | 4 | 19 | 23 | 5.75 |
| 3 | North Carolina State | 4 | 6 | 17 | 23 | 5.75 |
| 3 | Virginia Tech | 4 | 2 | 17 | 19 | 4.75 |
| 5 | Boston College | 4 | 2 | 15 | 17 | 4.25 |
| 6 | Florida State | 4 | 7 | 14 | 21 | 5.25 |
| 7 | Duke | 4 | 1 | 12 | 13 | 3.25 |
| 8 | Louisville | 4 | 1 | 10 | 11 | 2.75 |
| 9 | Wake Forest | 4 | 5 | 9 | 14 | 3.50 |
| 9 | Virginia | 3 | 3 | 9 | 12 | 4.00 |
| 9 | Pittsburgh | 4 | 3 | 9 | 12 | 3.00 |
| 9 | Georgia Tech | 4 | 0 | 9 | 9 | 2.25 |
| 13 | Miami (Florida) | 4 | 2 | 7 | 9 | 2.25 |
| 13 | Syracuse | 3 | 1 | 7 | 8 | 2.67 |