2025 Big 12 Conference Leaders Passes Defended - Games vs. Conference Teams Only through 11/08/2025
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Texas Tech | 7 | 7 | 42 | 49 | 7.00 |
| 2 | Kansas State | 7 | 9 | 36 | 45 | 6.43 |
| 3 | Arizona | 7 | 7 | 31 | 38 | 5.43 |
| 4 | Kansas | 7 | 2 | 30 | 32 | 4.57 |
| 5 | Cincinnati | 6 | 2 | 28 | 30 | 5.00 |
| 6 | Utah | 6 | 4 | 27 | 31 | 5.17 |
| 7 | Houston | 7 | 5 | 26 | 31 | 4.43 |
| 8 | Arizona State | 6 | 5 | 25 | 30 | 5.00 |
| 8 | Iowa State | 7 | 5 | 25 | 30 | 4.29 |
| 10 | Baylor | 6 | 3 | 24 | 27 | 4.50 |
| 11 | BYU | 6 | 8 | 23 | 31 | 5.17 |
| 11 | TCU | 6 | 8 | 23 | 31 | 5.17 |
| 11 | West Virginia | 7 | 6 | 23 | 29 | 4.14 |
| 14 | Colorado | 7 | 3 | 22 | 25 | 3.57 |
| 15 | Oklahoma State | 6 | 2 | 21 | 23 | 3.83 |
| 16 | UCF | 6 | 4 | 18 | 22 | 3.67 |