2025 Big 12 Conference Leaders Passes Defended - Games in August/September Only through 10/16/2025
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Arizona State | 5 | 4 | 26 | 30 | 6.00 |
| 2 | Colorado | 5 | 2 | 22 | 24 | 4.80 |
| 3 | Kansas State | 5 | 3 | 21 | 24 | 4.80 |
| 4 | Arizona | 4 | 6 | 20 | 26 | 6.50 |
| 5 | Baylor | 5 | 4 | 19 | 23 | 4.60 |
| 5 | Kansas | 5 | 3 | 19 | 22 | 4.40 |
| 7 | Iowa State | 5 | 6 | 18 | 24 | 4.80 |
| 8 | Houston | 4 | 5 | 16 | 21 | 5.25 |
| 9 | Texas Tech | 4 | 6 | 14 | 20 | 5.00 |
| 10 | Utah | 5 | 6 | 13 | 19 | 3.80 |
| 10 | UCF | 4 | 5 | 13 | 18 | 4.50 |
| 10 | West Virginia | 5 | 5 | 13 | 18 | 3.60 |
| 13 | TCU | 4 | 3 | 12 | 15 | 3.75 |
| 14 | Oklahoma State | 4 | 1 | 10 | 11 | 2.75 |
| 15 | BYU | 4 | 5 | 9 | 14 | 3.50 |
| 16 | Cincinnati | 4 | 0 | 6 | 6 | 1.50 |