2025 Conference USA Leaders Total Defense - Games vs. FBS non-Power 5 Conference Teams Only through 10/08/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Kennesaw State | 2 | 247 | 531 | 148 | 778 | 5.26 | 389.0 |
| 2 | Missouri State | 3 | 436 | 667 | 193 | 1103 | 5.72 | 367.7 |
| 3 | Jacksonville State | 3 | 643 | 678 | 204 | 1321 | 6.48 | 440.3 |
| 4 | UTEP | 4 | 632 | 762 | 269 | 1394 | 5.18 | 348.5 |
| 5 | Delaware | 3 | 443 | 779 | 197 | 1222 | 6.20 | 407.3 |
| 6 | Liberty | 5 | 997 | 793 | 320 | 1790 | 5.59 | 358.0 |
| 7 | Louisiana Tech | 3 | 274 | 822 | 205 | 1096 | 5.35 | 365.3 |
| 8 | Middle Tennessee State | 4 | 617 | 882 | 248 | 1499 | 6.04 | 374.8 |
| 9 | FIU | 3 | 425 | 931 | 215 | 1356 | 6.31 | 452.0 |
| 10 | New Mexico State | 4 | 695 | 1043 | 296 | 1738 | 5.87 | 434.5 |
| 11 | Western Kentucky | 5 | 1022 | 1089 | 342 | 2111 | 6.17 | 422.2 |
| 12 | Sam Houston State | 4 | 478 | 1199 | 276 | 1677 | 6.08 | 419.3 |