2025 Conference USA Leaders Total Defense - Games vs. FBS non-Power 5 Conference Teams Only through 12/13/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Missouri State | 9 | 1451 | 1900 | 602 | 3351 | 5.57 | 372.3 |
| 2 | Liberty | 11 | 1965 | 2229 | 742 | 4194 | 5.65 | 381.3 |
| 3 | Louisiana Tech | 9 | 1293 | 2285 | 612 | 3578 | 5.85 | 397.6 |
| 4 | UTEP | 10 | 1732 | 2253 | 719 | 3985 | 5.54 | 398.5 |
| 5 | Kennesaw State | 10 | 1759 | 2248 | 710 | 4007 | 5.64 | 400.7 |
| 6 | Delaware | 9 | 1379 | 2231 | 608 | 3610 | 5.94 | 401.1 |
| 7 | Middle Tennessee State | 10 | 1414 | 2598 | 682 | 4012 | 5.88 | 401.2 |
| 8 | Jacksonville State | 11 | 1732 | 2699 | 752 | 4431 | 5.89 | 402.8 |
| 9 | FIU | 10 | 1601 | 2513 | 700 | 4114 | 5.88 | 411.4 |
| 10 | New Mexico State | 10 | 1718 | 2436 | 725 | 4154 | 5.73 | 415.4 |
| 11 | Western Kentucky | 10 | 1897 | 2350 | 697 | 4247 | 6.09 | 424.7 |
| 12 | Sam Houston State | 10 | 2039 | 2682 | 681 | 4721 | 6.93 | 472.1 |