2025 Conference USA Leaders Total Defense - Games vs. Non-Conference Teams Only through 10/08/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Western Kentucky | 3 | 667 | 471 | 207 | 1138 | 5.50 | 379.3 |
| 2 | Liberty | 4 | 787 | 762 | 269 | 1549 | 5.76 | 387.3 |
| 3 | Delaware | 3 | 505 | 763 | 208 | 1268 | 6.10 | 422.7 |
| 4 | New Mexico State | 3 | 341 | 765 | 214 | 1106 | 5.17 | 368.7 |
| 5 | Louisiana Tech | 3 | 376 | 774 | 232 | 1150 | 4.96 | 383.3 |
| 6 | UTEP | 4 | 679 | 791 | 275 | 1470 | 5.35 | 367.5 |
| 7 | Jacksonville State | 4 | 644 | 798 | 276 | 1442 | 5.22 | 360.5 |
| 8 | Missouri State | 4 | 662 | 878 | 241 | 1540 | 6.39 | 385.0 |
| 9 | Sam Houston State | 3 | 542 | 886 | 202 | 1428 | 7.07 | 476.0 |
| 10 | Middle Tennessee State | 4 | 693 | 903 | 263 | 1596 | 6.07 | 399.0 |
| 11 | Kennesaw State | 4 | 614 | 939 | 274 | 1553 | 5.67 | 388.3 |
| 12 | FIU | 4 | 599 | 1161 | 282 | 1760 | 6.24 | 440.0 |