2025 Conference USA Leaders Total Defense - Games vs. FBS non-Power 5 Conference Teams Only through 09/13/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Missouri State | 1 | 191 | 83 | 57 | 274 | 4.81 | 274.0 |
| 2 | Louisiana Tech | 1 | 27 | 281 | 50 | 308 | 6.16 | 308.0 |
| 3 | UTEP | 1 | 127 | 233 | 61 | 360 | 5.90 | 360.0 |
| 4 | Middle Tennessee State | 1 | 203 | 166 | 60 | 369 | 6.15 | 369.0 |
| 5 | FIU | 1 | 135 | 343 | 82 | 478 | 5.83 | 478.0 |
| 6 | Delaware | 1 | 175 | 346 | 71 | 521 | 7.34 | 521.0 |
| 7 | Liberty | 2 | 496 | 198 | 130 | 694 | 5.34 | 347.0 |
| 8 | Western Kentucky | 2 | 480 | 410 | 124 | 890 | 7.18 | 445.0 |
| 9 | Jacksonville State | 2 | 418 | 526 | 132 | 944 | 7.15 | 472.0 |
| 10 | New Mexico State | 2 | 494 | 455 | 162 | 949 | 5.86 | 474.5 |
| 11 | Sam Houston State | 3 | 383 | 944 | 219 | 1327 | 6.06 | 442.3 |