2025 Conference USA Leaders Total Defense - Games vs. FBS non-Power 5 Conference Teams Only through 11/12/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Kennesaw State | 6 | 815 | 1397 | 451 | 2212 | 4.90 | 368.7 |
| 2 | Missouri State | 6 | 835 | 1301 | 401 | 2136 | 5.33 | 356.0 |
| 3 | Louisiana Tech | 7 | 888 | 1850 | 489 | 2738 | 5.60 | 391.1 |
| 4 | Middle Tennessee State | 7 | 981 | 1635 | 464 | 2616 | 5.64 | 373.7 |
| 5 | FIU | 7 | 994 | 1934 | 479 | 2928 | 6.11 | 418.3 |
| 6 | Jacksonville State | 7 | 1037 | 1715 | 464 | 2752 | 5.93 | 393.1 |
| 7 | Delaware | 7 | 1214 | 1674 | 466 | 2888 | 6.20 | 412.6 |
| 8 | UTEP | 7 | 1216 | 1336 | 486 | 2552 | 5.25 | 364.6 |
| 9 | Liberty | 8 | 1265 | 1665 | 527 | 2930 | 5.56 | 366.3 |
| 10 | New Mexico State | 8 | 1271 | 2025 | 585 | 3296 | 5.63 | 412.0 |
| 11 | Western Kentucky | 8 | 1446 | 1745 | 561 | 3191 | 5.69 | 398.9 |
| 12 | Sam Houston State | 7 | 1449 | 1785 | 476 | 3234 | 6.79 | 462.0 |