2025 Conference USA Leaders Total Defense - Games vs. Conference Teams Only through 10/08/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Liberty | 2 | 394 | 163 | 114 | 557 | 4.89 | 278.5 |
| 2 | FIU | 1 | 140 | 211 | 66 | 351 | 5.32 | 351.0 |
| 3 | Kennesaw State | 1 | 155 | 305 | 79 | 460 | 5.82 | 460.0 |
| 4 | Jacksonville State | 1 | 199 | 335 | 66 | 534 | 8.09 | 534.0 |
| 5 | UTEP | 2 | 255 | 380 | 151 | 635 | 4.21 | 317.5 |
| 6 | Louisiana Tech | 2 | 152 | 430 | 123 | 582 | 4.73 | 291.0 |
| 7 | Delaware | 2 | 268 | 433 | 126 | 701 | 5.56 | 350.5 |
| 8 | Middle Tennessee State | 2 | 227 | 455 | 117 | 682 | 5.83 | 341.0 |
| 9 | New Mexico State | 2 | 422 | 465 | 150 | 887 | 5.91 | 443.5 |
| 10 | Missouri State | 2 | 245 | 584 | 136 | 829 | 6.10 | 414.5 |
| 11 | Sam Houston State | 2 | 200 | 656 | 143 | 856 | 5.99 | 428.0 |
| 12 | Western Kentucky | 3 | 508 | 723 | 207 | 1231 | 5.95 | 410.3 |