2025 Conference USA Leaders Total Defense - Games in October Only through 10/09/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Liberty | 1 | 56 | 111 | 52 | 167 | 3.21 | 167.0 |
| 2 | Jacksonville State | 1 | 150 | 136 | 52 | 286 | 5.50 | 286.0 |
| 3 | Kennesaw State | 1 | 136 | 169 | 75 | 305 | 4.07 | 305.0 |
| 4 | New Mexico State | 1 | 69 | 244 | 65 | 313 | 4.82 | 313.0 |
| 5 | Delaware | 1 | 108 | 230 | 57 | 338 | 5.93 | 338.0 |
| 6 | Middle Tennessee State | 1 | 70 | 278 | 66 | 348 | 5.27 | 348.0 |
| 7 | Missouri State | 1 | 86 | 267 | 68 | 353 | 5.19 | 353.0 |
| 8 | Louisiana Tech | 1 | 110 | 290 | 63 | 400 | 6.35 | 400.0 |
| 9 | UTEP | 1 | 160 | 243 | 83 | 403 | 4.86 | 403.0 |
| 10 | Western Kentucky | 1 | 121 | 314 | 80 | 435 | 5.44 | 435.0 |
| 11 | FIU | 1 | 150 | 377 | 67 | 527 | 7.87 | 527.0 |
| 12 | Sam Houston State | 2 | 465 | 384 | 137 | 849 | 6.20 | 424.5 |