2025 Conference USA Leaders Total Defense - Games vs. Non-Conference Teams Only through 12/13/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Jacksonville State | 4 | 644 | 798 | 276 | 1442 | 5.22 | 360.5 |
| 2 | Louisiana Tech | 4 | 533 | 920 | 296 | 1453 | 4.91 | 363.3 |
| 3 | Western Kentucky | 4 | 793 | 673 | 286 | 1466 | 5.13 | 366.5 |
| 4 | UTEP | 4 | 679 | 791 | 275 | 1470 | 5.35 | 367.5 |
| 5 | New Mexico State | 4 | 535 | 984 | 280 | 1519 | 5.43 | 379.8 |
| 6 | Missouri State | 4 | 662 | 878 | 241 | 1540 | 6.39 | 385.0 |
| 7 | Liberty | 4 | 787 | 762 | 269 | 1549 | 5.76 | 387.3 |
| 8 | Kennesaw State | 4 | 614 | 939 | 274 | 1553 | 5.67 | 388.3 |
| 9 | Middle Tennessee State | 4 | 693 | 903 | 263 | 1596 | 6.07 | 399.0 |
| 10 | FIU | 4 | 599 | 1161 | 282 | 1760 | 6.24 | 440.0 |
| 11 | Delaware | 4 | 768 | 1077 | 268 | 1845 | 6.88 | 461.3 |
| 12 | Sam Houston State | 4 | 730 | 1172 | 284 | 1902 | 6.70 | 475.5 |