2025 Conference USA Leaders Total Defense - Games in August/September Only through 10/04/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | UTEP | 5 | 774 | 928 | 343 | 1702 | 4.96 | 340.4 |
| 2 | Louisiana Tech | 5 | 528 | 1204 | 355 | 1732 | 4.88 | 346.4 |
| 3 | Middle Tennessee State | 5 | 850 | 1080 | 314 | 1930 | 6.15 | 386.0 |
| 4 | Western Kentucky | 5 | 1054 | 880 | 334 | 1934 | 5.79 | 386.8 |
| 5 | Liberty | 5 | 1125 | 814 | 331 | 1939 | 5.86 | 387.8 |
| 6 | Jacksonville State | 5 | 843 | 1133 | 342 | 1976 | 5.78 | 395.2 |
| 7 | FIU | 4 | 589 | 995 | 281 | 1584 | 5.64 | 396.0 |
| 8 | Kennesaw State | 5 | 769 | 1244 | 353 | 2013 | 5.70 | 402.6 |
| 9 | Missouri State | 5 | 821 | 1195 | 309 | 2016 | 6.52 | 403.2 |
| 10 | Delaware | 4 | 665 | 966 | 277 | 1631 | 5.89 | 407.8 |
| 11 | New Mexico State | 4 | 694 | 986 | 299 | 1680 | 5.62 | 420.0 |
| 12 | Sam Houston State | 4 | 647 | 1287 | 288 | 1934 | 6.72 | 483.5 |