2025 Conference USA Leaders Total Defense - Games in August/September Only through 09/13/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Louisiana Tech | 3 | 281 | 663 | 200 | 944 | 4.72 | 314.7 |
| 2 | Liberty | 3 | 680 | 330 | 193 | 1010 | 5.23 | 336.7 |
| 3 | UTEP | 3 | 429 | 642 | 218 | 1071 | 4.91 | 357.0 |
| 4 | Western Kentucky | 3 | 633 | 515 | 196 | 1148 | 5.86 | 382.7 |
| 4 | Middle Tennessee State | 3 | 506 | 642 | 192 | 1148 | 5.98 | 382.7 |
| 6 | New Mexico State | 3 | 562 | 642 | 230 | 1204 | 5.23 | 401.3 |
| 7 | FIU | 3 | 449 | 784 | 215 | 1233 | 5.73 | 411.0 |
| 8 | Kennesaw State | 3 | 522 | 713 | 205 | 1235 | 6.02 | 411.7 |
| 9 | Delaware | 3 | 505 | 763 | 208 | 1268 | 6.10 | 422.7 |
| 10 | Missouri State | 3 | 591 | 728 | 184 | 1319 | 7.17 | 439.7 |
| 11 | Sam Houston State | 3 | 383 | 944 | 219 | 1327 | 6.06 | 442.3 |
| 12 | Jacksonville State | 3 | 526 | 840 | 202 | 1366 | 6.76 | 455.3 |