2025 Conference USA Leaders Total Defense - Games vs. Conference Teams Only through 09/13/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Louisiana Tech | 1 | 27 | 281 | 50 | 308 | 6.16 | 308.0 |
| 2 | Western Kentucky | 1 | 173 | 209 | 61 | 382 | 6.26 | 382.0 |
| 3 | Liberty | 1 | 338 | 52 | 62 | 390 | 6.29 | 390.0 |
| 4 | Sam Houston State | 1 | 105 | 401 | 86 | 506 | 5.88 | 506.0 |
| 5 | Jacksonville State | 1 | 199 | 335 | 66 | 534 | 8.09 | 534.0 |
| 6 | New Mexico State | 1 | 353 | 221 | 85 | 574 | 6.75 | 574.0 |