2025 Conference USA Leaders Rushing Defense - Games vs. Unranked Teams Only (AP Poll) through 11/01/2025
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Missouri State | 7 | 206 | 871 | 4.23 | 9 | 29.43 | 124.43 |
| 2 | Louisiana Tech | 8 | 257 | 1047 | 4.07 | 6 | 32.13 | 130.88 |
| 2 | FIU | 8 | 257 | 1275 | 4.96 | 12 | 32.13 | 159.38 |
| 4 | Sam Houston State | 7 | 269 | 1449 | 5.39 | 18 | 38.43 | 207.00 |
| 5 | Kennesaw State | 7 | 270 | 949 | 3.51 | 8 | 38.57 | 135.57 |
| 6 | Jacksonville State | 8 | 278 | 1111 | 4.00 | 12 | 34.75 | 138.88 |
| 7 | Delaware | 8 | 285 | 1413 | 4.96 | 18 | 35.63 | 176.63 |
| 8 | UTEP | 7 | 286 | 1017 | 3.56 | 9 | 40.86 | 145.29 |
| 9 | Liberty | 8 | 294 | 1403 | 4.77 | 12 | 36.75 | 175.38 |
| 10 | New Mexico State | 8 | 301 | 1131 | 3.76 | 7 | 37.63 | 141.38 |
| 11 | Middle Tennessee State | 8 | 313 | 1140 | 3.64 | 9 | 39.13 | 142.50 |
| 12 | Western Kentucky | 9 | 319 | 1599 | 5.01 | 11 | 35.44 | 177.67 |