2025 Conference USA Leaders Rushing Defense - Games vs. FBS Power 5 Conference Teams Only through 10/08/2025
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Middle Tennessee State | 1 | 31 | 153 | 4.94 | 3 | 31.00 | 153.00 |
| 1 | FIU | 1 | 31 | 209 | 6.74 | 2 | 31.00 | 209.00 |
| 3 | Louisiana Tech | 1 | 34 | 128 | 3.76 | 1 | 34.00 | 128.00 |
| 4 | Jacksonville State | 1 | 37 | 108 | 2.92 | 0 | 37.00 | 108.00 |
| 5 | Delaware | 1 | 39 | 130 | 3.33 | 2 | 39.00 | 130.00 |
| 6 | Sam Houston State | 1 | 41 | 264 | 6.44 | 4 | 41.00 | 264.00 |
| 7 | UTEP | 1 | 56 | 226 | 4.04 | 2 | 56.00 | 226.00 |
| 8 | Missouri State | 2 | 64 | 400 | 6.25 | 9 | 32.00 | 200.00 |
| 9 | Kennesaw State | 2 | 86 | 443 | 5.15 | 4 | 43.00 | 221.50 |