2025 Conference USA Leaders Total Defense - Games vs. Non-Conference Teams Only through 09/13/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | New Mexico State | 2 | 209 | 421 | 145 | 630 | 4.34 | 315.0 |
| 2 | Louisiana Tech | 2 | 254 | 382 | 150 | 636 | 4.24 | 318.0 |
| 3 | Sam Houston State | 2 | 278 | 543 | 133 | 821 | 6.17 | 410.5 |
| 4 | Jacksonville State | 2 | 327 | 505 | 136 | 832 | 6.12 | 416.0 |
| 5 | Liberty | 2 | 342 | 278 | 131 | 620 | 4.73 | 310.0 |
| 6 | UTEP | 3 | 429 | 642 | 218 | 1071 | 4.91 | 357.0 |
| 7 | FIU | 3 | 449 | 784 | 215 | 1233 | 5.73 | 411.0 |
| 8 | Western Kentucky | 2 | 460 | 306 | 135 | 766 | 5.67 | 383.0 |
| 9 | Delaware | 3 | 505 | 763 | 208 | 1268 | 6.10 | 422.7 |
| 10 | Middle Tennessee State | 3 | 506 | 642 | 192 | 1148 | 5.98 | 382.7 |
| 11 | Kennesaw State | 3 | 522 | 713 | 205 | 1235 | 6.02 | 411.7 |
| 12 | Missouri State | 3 | 591 | 728 | 184 | 1319 | 7.17 | 439.7 |