2025 Conference USA Leaders Total Defense - Games vs. FBS Power 5 Conference Teams Only through 09/13/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Jacksonville State | 1 | 108 | 314 | 70 | 422 | 6.03 | 422.0 |
| 2 | Louisiana Tech | 1 | 128 | 237 | 75 | 365 | 4.87 | 365.0 |
| 3 | Delaware | 1 | 130 | 268 | 70 | 398 | 5.69 | 398.0 |
| 4 | Middle Tennessee State | 1 | 153 | 283 | 58 | 436 | 7.52 | 436.0 |
| 5 | FIU | 1 | 209 | 200 | 64 | 409 | 6.39 | 409.0 |
| 6 | UTEP | 1 | 226 | 114 | 81 | 340 | 4.20 | 340.0 |
| 7 | Missouri State | 2 | 400 | 645 | 127 | 1045 | 8.23 | 522.5 |
| 8 | Kennesaw State | 2 | 443 | 498 | 142 | 941 | 6.63 | 470.5 |