2025 Conference USA Leaders Total Defense - Games vs. Non-Conference Teams Only through 01/02/2026
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Louisiana Tech | 5 | 578 | 1231 | 370 | 1809 | 4.89 | 361.8 |
| 2 | Jacksonville State | 5 | 732 | 927 | 338 | 1659 | 4.91 | 331.8 |
| 3 | Western Kentucky | 5 | 912 | 931 | 370 | 1843 | 4.98 | 368.6 |
| 4 | UTEP | 4 | 679 | 791 | 275 | 1470 | 5.35 | 367.5 |
| 5 | New Mexico State | 4 | 535 | 984 | 280 | 1519 | 5.43 | 379.8 |
| 6 | Liberty | 4 | 787 | 762 | 269 | 1549 | 5.76 | 387.3 |
| 7 | Kennesaw State | 5 | 917 | 1059 | 336 | 1976 | 5.88 | 395.2 |
| 8 | Middle Tennessee State | 4 | 693 | 903 | 263 | 1596 | 6.07 | 399.0 |
| 9 | Delaware | 5 | 872 | 1308 | 345 | 2180 | 6.32 | 436.0 |
| 10 | FIU | 5 | 785 | 1456 | 353 | 2241 | 6.35 | 448.2 |
| 11 | Missouri State | 5 | 733 | 1166 | 297 | 1899 | 6.39 | 379.8 |
| 12 | Sam Houston State | 4 | 730 | 1172 | 284 | 1902 | 6.70 | 475.5 |