2025 Conference USA Leaders Total Defense - Games in October Only through 10/08/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Liberty | 1 | 56 | 111 | 52 | 167 | 3.21 | 167.0 |
| 2 | New Mexico State | 1 | 69 | 244 | 65 | 313 | 4.82 | 313.0 |
| 3 | Middle Tennessee State | 1 | 70 | 278 | 66 | 348 | 5.27 | 348.0 |
| 4 | Missouri State | 1 | 86 | 267 | 68 | 353 | 5.19 | 353.0 |
| 5 | Sam Houston State | 1 | 95 | 255 | 57 | 350 | 6.14 | 350.0 |
| 6 | Delaware | 1 | 108 | 230 | 57 | 338 | 5.93 | 338.0 |
| 7 | Western Kentucky | 1 | 121 | 314 | 80 | 435 | 5.44 | 435.0 |
| 8 | FIU | 1 | 150 | 377 | 67 | 527 | 7.87 | 527.0 |
| 9 | UTEP | 1 | 160 | 243 | 83 | 403 | 4.86 | 403.0 |