2021 Conference USA Leaders Total Defense - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Southern Mississippi | 4 | 353 | 1009 | 246 | 1362 | 5.54 | 340.5 |
| 2 | UTSA | 5 | 508 | 1277 | 327 | 1785 | 5.46 | 357.0 |
| 3 | Louisiana Tech | 4 | 518 | 1511 | 307 | 2029 | 6.61 | 507.3 |
| 4 | UTEP | 5 | 634 | 1098 | 327 | 1732 | 5.30 | 346.4 |
| 5 | Florida International | 4 | 646 | 1164 | 305 | 1810 | 5.93 | 452.5 |
| 6 | UAB | 5 | 736 | 1293 | 306 | 2029 | 6.63 | 405.8 |
| 7 | Old Dominion | 5 | 800 | 993 | 359 | 1793 | 4.99 | 358.6 |
| 8 | Middle Tennessee | 5 | 841 | 1016 | 355 | 1857 | 5.23 | 371.4 |
| 9 | Rice | 4 | 910 | 927 | 265 | 1837 | 6.93 | 459.3 |
| 10 | North Texas | 5 | 993 | 1218 | 355 | 2211 | 6.23 | 442.2 |
| 11 | Florida Atlantic | 4 | 1014 | 549 | 279 | 1563 | 5.60 | 390.8 |
| 12 | Marshall | 5 | 1077 | 1123 | 419 | 2200 | 5.25 | 440.0 |
| 13 | Western Kentucky | 5 | 1127 | 1330 | 393 | 2457 | 6.25 | 491.4 |
| 14 | Charlotte | 4 | 1135 | 495 | 266 | 1630 | 6.13 | 407.5 |