2020 Conference USA Leaders Total Defense - Games vs. Non-Conference Teams Only through 01/11/2021
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Charlotte | 2 | 582 | 331 | 122 | 913 | 7.48 | 456.5 |
| 2 | Florida Atlantic | 3 | 516 | 434 | 195 | 950 | 4.87 | 316.7 |
| 3 | Florida International | 2 | 504 | 467 | 160 | 971 | 6.07 | 485.5 |
| 4 | Marshall | 4 | 378 | 637 | 244 | 1015 | 4.16 | 253.8 |
| 5 | Middle Tennessee | 3 | 672 | 584 | 221 | 1256 | 5.68 | 418.7 |
| 6 | UAB | 4 | 718 | 671 | 271 | 1389 | 5.13 | 347.3 |
| 7 | UTEP | 4 | 411 | 1009 | 221 | 1420 | 6.43 | 355.0 |
| 8 | Southern Mississippi | 4 | 805 | 1002 | 264 | 1807 | 6.84 | 451.8 |
| 9 | North Texas | 3 | 955 | 960 | 226 | 1915 | 8.47 | 638.3 |
| 10 | Louisiana Tech | 4 | 938 | 1018 | 268 | 1956 | 7.30 | 489.0 |
| 11 | UTSA | 5 | 930 | 1125 | 339 | 2055 | 6.06 | 411.0 |
| 12 | Western Kentucky | 5 | 1026 | 1067 | 371 | 2093 | 5.64 | 418.6 |