2021 National Leaders Long All Purpose Plays - Games vs. Conference Teams Only through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Brian Battie | S Florida | SO | RB | 8 | 4 | 4 | 3 | 3 | 3 | 3 | 3 |
| 2 | Marcus Jones | Houston | SR | CB | 9 | 6 | 6 | 3 | 3 | 3 | 2 | 2 |
| 2 | Zonovan Knight | NC State | SO | RB | 8 | 4 | 3 | 3 | 3 | 3 | 2 | 2 |
| 2 | Malik Knowles | Kansas St | JR | WR | 9 | 9 | 6 | 4 | 4 | 2 | 2 | 2 |
| 2 | Matt Landers | Toledo | JR | WR | 8 | 4 | 3 | 2 | 2 | 2 | 2 | 0 |
| 2 | Bryan Massey | SMU | SO | S | 8 | 8 | 4 | 3 | 2 | 2 | 2 | 2 |
| 2 | Jack Sorenson | Miami (Oh) | SR | WR | 8 | 9 | 5 | 4 | 2 | 2 | 2 | 0 |
| 2 | Jaylen Stinson | Duke | SO | S | 8 | 3 | 2 | 2 | 2 | 2 | 2 | 1 |
| 2 | Titus Swen | Wyoming | JR | RB | 8 | 3 | 3 | 2 | 2 | 2 | 2 | 1 |
| 10 | Israel Abanikanda | Pittsburgh | SO | RB | 8 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 10 | Kris Abrams-Draine | Missouri | SO | DB | 8 | 2 | 1 | 1 | 1 | 1 | 1 | 1 |
| 10 | Devon Achane | Texas A&M | SO | RB | 8 | 7 | 3 | 2 | 2 | 1 | 1 | 1 |
| 10 | Carlinos Acie | Navy | SR | SB | 8 | 2 | 2 | 2 | 2 | 1 | 1 | 1 |
| 10 | Kazmeir Allen | UCLA | JR | RB | 9 | 5 | 4 | 3 | 2 | 2 | 1 | 1 |
| 10 | Andrel Anthony | Michigan | FR | WR | 8 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 10 | Jaheim Bell | S Carolina | SO | TE | 8 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 10 | Kivon Bennett | Ark St | JR | DL | 8 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 10 | Zavier Betts | Nebraska | FR | WR | 9 | 2 | 1 | 1 | 1 | 1 | 1 | 0 |
| 10 | Reed Blankenship | MTSU | SR | S | 8 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 10 | Zion Bowens | Hawai'i | SR | WR | 7 | 2 | 1 | 1 | 1 | 1 | 1 | 1 |
| 10 | Stephan Bracey | Wisconsin | SO | WR | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 10 | Brian Brewton | UConn | FR | RB | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 10 | Ji'Ayir Brown | Penn State | SR | S | 9 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 10 | Treylon Burks | Arkansas | JR | WR | 8 | 8 | 4 | 3 | 2 | 1 | 1 | 0 |
| 10 | Jalon Calhoun | Duke | JR | WR | 8 | 4 | 1 | 1 | 1 | 1 | 1 | 0 |
| 10 | Grayson Cash | UAB | JR | S | 8 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 10 | Tyrese Chambers | FIU | SO | WR | 8 | 8 | 7 | 6 | 5 | 2 | 1 | 1 |
| 10 | Trevon Clark | California | SR | WR | 9 | 4 | 1 | 1 | 1 | 1 | 1 | 0 |
| 10 | Trey Cobb | App St | SR | ILB | 9 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 10 | Tyleek Collins | UNLV | SR | WR | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 10 | Derius Davis | TCU | SR | WR | 9 | 9 | 6 | 3 | 3 | 2 | 1 | 1 |
| 10 | Will Derrick | La-Monroe | JR | WR | 8 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 10 | Jahan Dotson | Penn State | SR | WR | 9 | 9 | 4 | 1 | 1 | 1 | 1 | 0 |
| 10 | Trestan Ebner | Baylor | SR | RB | 10 | 8 | 4 | 3 | 2 | 1 | 1 | 1 |
| 10 | Tiyon Evans | Tennessee | JR | RB | 5 | 3 | 3 | 1 | 1 | 1 | 1 | 1 |
| 10 | Johnny Ford | FAU | SO | RB | 8 | 8 | 2 | 2 | 2 | 1 | 1 | 0 |
| 10 | Jahmyr Gibbs | Ga Tech | FR | RB | 8 | 9 | 6 | 6 | 5 | 4 | 1 | 1 |
| 10 | Breece Hall | Iowa State | JR | RB | 9 | 13 | 7 | 4 | 3 | 3 | 1 | 0 |
| 10 | Camron Harrell | USM | JR | DB | 8 | 4 | 2 | 2 | 2 | 1 | 1 | 1 |
| 10 | Tyler Harrell | Louisville | SO | WR | 8 | 8 | 4 | 3 | 2 | 2 | 1 | 1 |
| 10 | Jayden Harrison | Marshall | SO | WR | 8 | 3 | 1 | 1 | 1 | 1 | 1 | 1 |
| 10 | Maquel Haywood | Navy | FR | SB | 6 | 4 | 2 | 1 | 1 | 1 | 1 | 1 |
| 10 | Joe Joe Headen | ODU | SR | S | 8 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 10 | Ta'Zhawn Henry | Houston | JR | RB | 9 | 2 | 1 | 1 | 1 | 1 | 1 | 1 |
| 10 | Jimmy Horn Jr. | S Florida | FR | WR | 8 | 3 | 1 | 1 | 1 | 1 | 1 | 0 |
| 10 | Dae Dae Hunter | Hawai'i | SO | RB | 6 | 3 | 2 | 2 | 2 | 2 | 1 | 0 |
| 10 | LaMareon James | ODU | FR | CB | 8 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 10 | Steve Jenkins | UNLV | JR | WR | 8 | 5 | 3 | 1 | 1 | 1 | 1 | 0 |
| 10 | Montrell Johnson | La-Lafytte | FR | RB | 9 | 3 | 2 | 1 | 1 | 1 | 1 | 1 |
| 10 | Charlie Jones | Iowa | SR | WR | 10 | 9 | 4 | 2 | 2 | 2 | 1 | 1 |
| 10 | Jack Jones | Ariz St | SR | DB | 8 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 10 | Alan Lamar | Ark St | SR | RB | 8 | 8 | 2 | 2 | 1 | 1 | 1 | 1 |
| 10 | Brandon Lewis | Air Force | SR | WR | 8 | 6 | 3 | 2 | 1 | 1 | 1 | 1 |
| 10 | Isaiah Likely | Coast Car | SR | TE | 8 | 4 | 2 | 2 | 2 | 1 | 1 | 1 |
| 10 | Marion Lukes | CMU | FR | RB | 8 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 10 | Michael Mathison | Akron | SO | WR | 7 | 4 | 2 | 2 | 1 | 1 | 1 | 1 |
| 10 | Sincere McCormick | UTSA | JR | RB | 9 | 4 | 4 | 3 | 3 | 2 | 1 | 0 |
| 10 | Lincoln Pare | Ark St | FR | RB | 8 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 10 | Nathaniel Peat | Stanford | JR | RB | 9 | 5 | 1 | 1 | 1 | 1 | 1 | 0 |
| 10 | Kyle Philips | UCLA | JR | WR | 8 | 4 | 4 | 3 | 2 | 2 | 1 | 0 |
| 10 | Kalil Pimpleton | CMU | JR | WR | 8 | 8 | 6 | 4 | 3 | 3 | 1 | 1 |
| 10 | TJ Pledger | Utah | JR | RB | 10 | 5 | 3 | 2 | 1 | 1 | 1 | 1 |
| 10 | Brennan Presley | Okla St | SO | WR | 10 | 6 | 3 | 1 | 1 | 1 | 1 | 1 |
| 10 | Clint Ratkovich | N Illinois | SR | RB | 9 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 10 | Nikko Reed | Colorado | FR | CB | 7 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 10 | Berdale Robins | Nevada | SR | DB | 7 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 10 | Tyrell Robinson | Army | SO | RB | 3 | 3 | 3 | 3 | 2 | 2 | 1 | 0 |
| 10 | Armani Rogers | Ohio | SR | QB | 8 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 10 | Trayvon Rudolph | N Illinois | FR | WR | 9 | 11 | 5 | 4 | 4 | 4 | 1 | 1 |
| 10 | Savon Scarver | Utah State | SR | WR | 9 | 3 | 1 | 1 | 1 | 1 | 1 | 1 |
| 10 | Christian Sims | BGSU | JR | TE | 8 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 10 | Ainias Smith | Texas A&M | JR | WR | 8 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 10 | Chris Smith | La-Lafytte | SO | RB | 9 | 5 | 3 | 2 | 2 | 2 | 1 | 0 |
| 10 | JD Spielman | TCU | SR | WR | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 10 | Cameron Stone | Wyoming | SO | CB | 8 | 2 | 1 | 1 | 1 | 1 | 1 | 1 |
| 10 | Jacquez Stuart | Toledo | FR | RB | 8 | 3 | 2 | 1 | 1 | 1 | 1 | 1 |
| 10 | Jason Taylor II | Okla St | JR | S | 10 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 10 | Sean Tyler | W Mich | SO | RB | 8 | 3 | 2 | 2 | 2 | 1 | 1 | 1 |
| 10 | Deuce Vaughn | Kansas St | SO | RB | 9 | 8 | 5 | 3 | 2 | 1 | 1 | 0 |
| 10 | Jalen Virgil | App St | SR | WR | 7 | 4 | 3 | 1 | 1 | 1 | 1 | 1 |
| 10 | Kenneth Walker III | Mich St | JR | RB | 9 | 8 | 4 | 4 | 2 | 2 | 1 | 1 |
| 10 | Anthony Watkins | Tulsa | SO | RB | 8 | 5 | 3 | 2 | 2 | 2 | 1 | 1 |
| 10 | Christian Wells | App St | SO | WR | 9 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 10 | Ja'Cquez Williams | La-Monroe | SR | LB | 8 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |