2021 National Leaders Long All Purpose Plays - Games in October Only through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Marcus Jones | Houston | SR | CB | 4 | 3 | 3 | 2 | 2 | 2 | 2 | 2 |
| 1 | Bryan Massey | SMU | SO | S | 4 | 6 | 4 | 3 | 2 | 2 | 2 | 2 |
| 3 | Kris Abrams-Draine | Missouri | SO | DB | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 3 | Devon Achane | Texas A&M | SO | RB | 4 | 5 | 2 | 1 | 1 | 1 | 1 | 1 |
| 3 | Andrel Anthony | Michigan | FR | WR | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 3 | Brian Battie | S Florida | SO | RB | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 3 | Jaheim Bell | S Carolina | SO | TE | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 3 | Zavier Betts | Nebraska | FR | WR | 4 | 2 | 1 | 1 | 1 | 1 | 1 | 0 |
| 3 | Reed Blankenship | MTSU | SR | S | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 3 | Chase Brown | Illinois | SO | RB | 4 | 2 | 1 | 1 | 1 | 1 | 1 | 0 |
| 3 | Jalon Calhoun | Duke | JR | WR | 4 | 3 | 1 | 1 | 1 | 1 | 1 | 0 |
| 3 | Grayson Cash | UAB | JR | S | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 3 | Derius Davis | TCU | SR | WR | 5 | 5 | 2 | 1 | 1 | 1 | 1 | 1 |
| 3 | Will Derrick | La-Monroe | JR | WR | 5 | 2 | 1 | 1 | 1 | 1 | 1 | 0 |
| 3 | Tiyon Evans | Tennessee | JR | RB | 3 | 2 | 2 | 1 | 1 | 1 | 1 | 1 |
| 3 | Johnny Ford | FAU | SO | RB | 4 | 3 | 2 | 2 | 2 | 1 | 1 | 0 |
| 3 | Justin Hall | Ball State | SR | WR | 4 | 4 | 1 | 1 | 1 | 1 | 1 | 1 |
| 3 | Camron Harrell | USM | JR | DB | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 3 | Tyler Harrell | Louisville | SO | WR | 4 | 2 | 2 | 2 | 2 | 2 | 1 | 1 |
| 3 | Dae Dae Hunter | Hawai'i | SO | RB | 2 | 2 | 2 | 2 | 2 | 2 | 1 | 0 |
| 3 | LaMareon James | ODU | FR | CB | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 3 | Montrell Johnson | La-Lafytte | FR | RB | 4 | 2 | 1 | 1 | 1 | 1 | 1 | 1 |
| 3 | Malik Knowles | Kansas St | JR | WR | 4 | 3 | 1 | 1 | 1 | 1 | 1 | 1 |
| 3 | Alan Lamar | Ark St | SR | RB | 4 | 5 | 2 | 2 | 1 | 1 | 1 | 1 |
| 3 | Isaiah Likely | Coast Car | SR | TE | 4 | 4 | 2 | 2 | 2 | 1 | 1 | 1 |
| 3 | Sincere McCormick | UTSA | JR | RB | 4 | 2 | 2 | 1 | 1 | 1 | 1 | 0 |
| 3 | Nathan Parodi | Arkansas | JR | DB | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 3 | Traveon Redd | Wk Forest | SR | DB | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 3 | Jayden Reed | Mich St | JR | WR | 4 | 4 | 3 | 1 | 1 | 1 | 1 | 0 |
| 3 | Armani Rogers | Ohio | SR | QB | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 3 | Trayvon Rudolph | N Illinois | FR | WR | 4 | 3 | 3 | 2 | 2 | 2 | 1 | 1 |
| 3 | Savon Scarver | Utah State | SR | WR | 4 | 2 | 1 | 1 | 1 | 1 | 1 | 1 |
| 3 | Christian Sims | BGSU | JR | TE | 5 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 3 | Ainias Smith | Texas A&M | JR | WR | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 3 | Chris Smith | La-Lafytte | SO | RB | 4 | 4 | 2 | 2 | 2 | 2 | 1 | 0 |
| 3 | JD Spielman | TCU | SR | WR | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 3 | Jason Taylor II | Okla St | JR | S | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 3 | Kenneth Walker III | Mich St | JR | RB | 4 | 2 | 2 | 2 | 1 | 1 | 1 | 1 |
| 3 | Anthony Watkins | Tulsa | SO | RB | 4 | 3 | 3 | 2 | 2 | 2 | 1 | 1 |
| 3 | Christian Wells | App St | SO | WR | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 3 | Kyren Williams | Notre Dame | SO | RB | 4 | 3 | 2 | 1 | 1 | 1 | 1 | 1 |