2025 Big 12 Conference Leaders Passes Defended - Games vs. FBS Power 5 Conference Teams Only through 10/17/2025
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Kansas State | 5 | 6 | 24 | 30 | 6.00 |
| 1 | Texas Tech | 4 | 6 | 19 | 25 | 6.25 |
| 1 | TCU | 5 | 6 | 15 | 21 | 4.20 |
| 1 | BYU | 4 | 6 | 11 | 17 | 4.25 |
| 5 | Arizona | 4 | 4 | 20 | 24 | 6.00 |
| 6 | Arizona State | 4 | 3 | 17 | 20 | 5.00 |
| 6 | Houston | 4 | 3 | 16 | 19 | 4.75 |
| 6 | Iowa State | 5 | 3 | 15 | 18 | 3.60 |
| 6 | Utah | 4 | 3 | 11 | 14 | 3.50 |
| 6 | UCF | 4 | 3 | 7 | 10 | 2.50 |
| 6 | West Virginia | 4 | 3 | 7 | 10 | 2.50 |
| 12 | Kansas | 5 | 2 | 24 | 26 | 5.20 |
| 12 | Baylor | 5 | 2 | 20 | 22 | 4.40 |
| 12 | Oklahoma State | 4 | 2 | 16 | 18 | 4.50 |
| 12 | Colorado | 5 | 2 | 10 | 12 | 2.40 |
| 16 | Cincinnati | 4 | 0 | 17 | 17 | 4.25 |