2025 Big 12 Conference Leaders Passes Defended - Games vs. FBS Power 5 Conference Teams Only through 01/09/2026
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Texas Tech | 12 | 15 | 60 | 75 | 6.25 |
| 2 | Arizona | 11 | 17 | 50 | 67 | 6.09 |
| 3 | Arizona State | 11 | 7 | 56 | 63 | 5.73 |
| 4 | Kansas State | 10 | 13 | 43 | 56 | 5.60 |
| 5 | Houston | 11 | 9 | 46 | 55 | 5.00 |
| 6 | Utah | 11 | 12 | 41 | 53 | 4.82 |
| 7 | Iowa State | 10 | 8 | 37 | 45 | 4.50 |
| 8 | Kansas | 10 | 2 | 42 | 44 | 4.40 |
| 9 | BYU | 12 | 15 | 37 | 52 | 4.33 |
| 10 | TCU | 12 | 14 | 35 | 49 | 4.08 |
| 11 | West Virginia | 10 | 8 | 32 | 40 | 4.00 |
| 12 | UCF | 10 | 7 | 32 | 39 | 3.90 |
| 13 | Baylor | 11 | 6 | 34 | 40 | 3.64 |
| 14 | Cincinnati | 10 | 2 | 34 | 36 | 3.60 |
| 15 | Colorado | 10 | 5 | 29 | 34 | 3.40 |
| 16 | Oklahoma State | 10 | 5 | 28 | 33 | 3.30 |