2025 Big 12 Conference Leaders Passes Defended - Games vs. FBS Power 5 Conference Teams Only through 09/18/2025
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Arizona | 1 | 0 | 8 | 8 | 8.00 |
| 2 | Texas Tech | 1 | 2 | 5 | 7 | 7.00 |
| 2 | Arizona State | 1 | 0 | 7 | 7 | 7.00 |
| 4 | Kansas State | 2 | 1 | 12 | 13 | 6.50 |
| 5 | Iowa State | 2 | 1 | 7 | 8 | 4.00 |
| 5 | Houston | 1 | 2 | 2 | 4 | 4.00 |
| 5 | West Virginia | 1 | 1 | 3 | 4 | 4.00 |
| 5 | Kansas | 1 | 0 | 4 | 4 | 4.00 |
| 9 | Baylor | 2 | 1 | 5 | 6 | 3.00 |
| 9 | BYU | 1 | 2 | 1 | 3 | 3.00 |
| 11 | Colorado | 2 | 1 | 4 | 5 | 2.50 |
| 12 | TCU | 1 | 1 | 1 | 2 | 2.00 |
| 12 | Utah | 1 | 1 | 1 | 2 | 2.00 |
| 12 | Cincinnati | 1 | 0 | 2 | 2 | 2.00 |