2025 Big 12 Conference Leaders Passes Defended - Games in August/September Only through 09/18/2025
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Arizona | 3 | 5 | 17 | 22 | 7.33 |
| 1 | Houston | 3 | 5 | 10 | 15 | 5.00 |
| 3 | Iowa State | 4 | 4 | 14 | 18 | 4.50 |
| 3 | Texas Tech | 3 | 4 | 11 | 15 | 5.00 |
| 3 | West Virginia | 3 | 4 | 10 | 14 | 4.67 |
| 3 | Baylor | 3 | 4 | 8 | 12 | 4.00 |
| 3 | Utah | 3 | 4 | 8 | 12 | 4.00 |
| 8 | Colorado | 3 | 2 | 11 | 13 | 4.33 |
| 8 | Kansas | 3 | 2 | 10 | 12 | 4.00 |
| 8 | UCF | 2 | 2 | 9 | 11 | 5.50 |
| 8 | BYU | 2 | 2 | 3 | 5 | 2.50 |
| 12 | Arizona State | 3 | 1 | 17 | 18 | 6.00 |
| 12 | Kansas State | 4 | 1 | 16 | 17 | 4.25 |
| 12 | TCU | 2 | 1 | 4 | 5 | 2.50 |
| 12 | Oklahoma State | 2 | 1 | 2 | 3 | 1.50 |
| 16 | Cincinnati | 3 | 0 | 5 | 5 | 1.67 |